Basic Information
VIS ID
TVIS44031721
Fusion event
HTLV-1-NOTCH1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
q34.3
Reference genome
NCBI36/hg18
Start
138518219/136503946 (Hg38)
End
138518219/136503946 (Hg38)
Orient
+
Location type
Intronic
Target gene
NOTCH1
miRNAs that regulate target gene
hsa-mir-27b-3p ; hsa-mir-24-3p ; hsa-mir-23b-3p ; hsa-mir-34a-5p ; hsa-mir-30a-5p ; hsa-mir-326 ; hsa-mir-129-5p ; hsa-mir-144-3p ; hsa-mir-449a ; hsa-mir-34b-3p ; hsa-mir-34c-5p ; hsa-mir-10b-5p ; hsa-mir-181a-5p ; hsa-mir-30b-5p ; hsa-mir-139-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30e-5p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-5088-3p ; hsa-mir-335-3p ; hsa-mir-627-3p ; hsa-mir-6761-3p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-1277-3p ; hsa-mir-363-3p ; hsa-mir-9-5p ; hsa-mir-410-3p ; hsa-mir-101-3p ; hsa-mir-935 ; hsa-mir-30a-3p ; hsa-mir-146a-5p ; hsa-mir-296-5p
Nearest miRNA
hsa-let-7a-1/Upstream/1653139; hsa-mir-126/Downstream/15622;
Nearest TSS
ENST00000422679/Upstream/20187; ENST00000439501/Downstream/899;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/688, chr9-CpG: 111/Downstream/642
Nearest cancer related gene
NOTCH1(TSG, No orient, 0)
Upstream sequence
CCAGCAGAACTGACAGGCAAACCCACCAGGGTCAGGCACACGAAGGGCACAACCAACCTGGCTCCTGGGTCCAGCTGCCCCAGATCGAGTAGGCATGGGC
Downstream sequence
GGGAGCCTTGTGGGGTGCCCCCTGCACTCAAGCTGCTCCTGCCTGTGTTCTCCCACCGTGGGACCCCCCACCCCCACCAGCTCCTCCTCCAACTGCAAGG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate