Basic Information
VIS ID
TVIS44031722
Fusion event
HTLV-1-MCCC2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
NCBI36/hg18
Start
70935643/71604060 (Hg38)
End
70935643/71604060 (Hg38)
Orient
+
Location type
Intronic
Target gene
MCCC2
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-769-5p ; hsa-mir-6864-3p ; hsa-mir-3606-5p ; hsa-mir-3672 ; hsa-mir-661 ; hsa-mir-4786-5p ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-4714-3p ; hsa-mir-1244 ; hsa-mir-199a-3p ; hsa-mir-199b-3p ; hsa-mir-222-5p ; hsa-mir-3129-5p ; hsa-mir-3614-5p ; hsa-mir-6500-3p ; hsa-mir-936
Nearest miRNA
hsa-mir-10397/Upstream/11900357; hsa-mir-103a-1/Downstream/565407;
Nearest TSS
ENST00000502646/Upstream/1551; ENST00000505435/Downstream/320;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/16474, chr5-CpG: 63/Downstream/115030
Upstream sequence
GAAAACAGTATCAGAAGGCAATATGTATAAATTATTATATGAATTCTGTGGATGGCTTTTGTATTGGTTTAGAAGAAGGAAAGATACTTTTCCACCTTAA
Downstream sequence
CTCTTTAAGAATTTATGATGTTTCTGGGGCTTTAGCTGGTCCTCAAAGGAGAGAAGGTTCTAACCATTTCGAGAAGAATTTTGCACAGAGGTGGGAAAGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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