Basic Information
VIS ID
TVIS44031774
Fusion event
HTLV-1-LDLRAD4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr18
Cytoband
p11.21
Reference genome
NCBI36/hg18
Start
13457931/13467932 (Hg38)
End
13457931/13467932 (Hg38)
Orient
-
Location type
Intronic
Target gene
LDLRAD4
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-3658 ; hsa-mir-7856-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-3194-5p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-6752-3p ; hsa-mir-4530 ; hsa-mir-3918 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-2114-5p ; hsa-mir-7160-3p ; hsa-mir-6510-5p
Nearest miRNA
hsa-mir-3976/Upstream/7906; hsa-mir-1-2/Downstream/143182;
Nearest TSS
ENST00000575820/Upstream/2907; ENST00000587440/Downstream/2891;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/80245, chr18-CpG: 63/Downstream/30830
Upstream sequence
ctatggctggatgattggatgatttttgataagggctccaagtccatttaatgggaaagaatagtcttttcaacaaatgatgctggggcaactgggttcc
Downstream sequence
tgcatcaaaagaagggagttggaccctatctcatatcaggtacaaaaattagcttgaaatgtatcaacgacttacatttaagagccaagagcataaaatt
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate