Basic Information
VIS ID
TVIS44031793
Fusion event
HTLV-1-ADAM12 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q26.2
Reference genome
NCBI36/hg18
Start
127893255/126214696 (Hg38)
End
127893255/126214696 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
ADAM12
miRNAs that regulate target gene
hsa-mir-29b-3p ; hsa-mir-1-3p ; hsa-mir-218-5p ; hsa-mir-135b-5p ; hsa-mir-29a-3p ; hsa-mir-29c-3p ; hsa-mir-30b-3p ; hsa-mir-30d-3p ; hsa-mir-200b-3p ; hsa-mir-200c-3p ; hsa-mir-1185-5p ; hsa-mir-1224-5p ; hsa-mir-129-5p ; hsa-mir-1304-5p ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-3915 ; hsa-mir-4689 ; hsa-mir-586 ; hsa-mir-6858-5p ; hsa-mir-8055
Nearest miRNA
hsa-mir-107/Upstream/394874; hsa-mir-202/Downstream/3628603;
Nearest TSS
ENST00000439456/Upstream/59391; ENST00000473861/Downstream/173759;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/317727, chr10-CpG: 132/Downstream/172890
Upstream sequence
GGAAGATTCACTGATTGACAGTACCCTTTTGCAGTGATTGAGTTTCTGTGTGCATTTGTTTCATGGGAAAAAGCACCAAATTTTTAGAAAATGAAGAAAT
Downstream sequence
TGGGCCACTAATGAGAGCAAACGTTTTTGAGAAGAGTATCTATGATGTTCATTATGACTCAGCTTGGAGTCCTAGTTAATCACAGGTGGCTATGCACAGA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate