Basic Information
VIS ID
TVIS44031800
Fusion event
HTLV-1-WWC2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q35.1
Reference genome
NCBI36/hg18
Start
184411747/183253600 (Hg38)
End
184411747/183253600 (Hg38)
Orient
+
Location type
Intronic
Target gene
WWC2
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-21-5p ; hsa-mir-5584-3p ; hsa-mir-7850-5p ; hsa-mir-5004-3p ; hsa-mir-3658 ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-3152-5p ; hsa-mir-4774-3p ; hsa-mir-6836-3p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-664b-3p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-150-5p ; hsa-mir-3121-5p ; hsa-mir-6832-3p ; hsa-mir-4699-3p ; hsa-mir-8485 ; hsa-mir-561-5p ; hsa-mir-615-5p ; hsa-mir-3936 ; hsa-mir-7156-3p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-3944-5p ; hsa-mir-766-3p ; hsa-mir-6849-3p ; hsa-mir-4691-3p ; hsa-mir-596
Nearest miRNA
hsa-mir-12113/Upstream/1084222; hsa-mir-3945/Downstream/1597413;
Nearest TSS
ENST00000502981/Upstream/12966; ENST00000506225/Downstream/12269;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/153374, chr4-CpG: 57/Downstream/144811
Upstream sequence
GCTGGGTATGCTCACTCACATTTTAAAGATGGGGGAAAGAAGTGGGTGACAGCTGAGTGCAGAGACAGGCCCAGAGACTGGTGTGCAAGGCTGCTGCTCC
Downstream sequence
CACTCCGGCCTCTCACCAGTAGACCACACCTCTTTCTGGTAAGGTCAAGTTAGGAAAATCTGGACAGCATGTCAACACCAAATTTGGCTTAGGCTGTGTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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