Basic Information
VIS ID
TVIS44031819
Fusion event
HTLV-1-PRPF4B integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
p25.2
Reference genome
NCBI36/hg18
Start
3970501/4025268 (Hg38)
End
3970501/4025268 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRPF4B
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-371a-5p ; hsa-mir-7843-3p ; hsa-mir-4665-5p ; hsa-mir-5010-5p ; hsa-mir-1275 ; hsa-mir-4525 ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-625-5p ; hsa-mir-6825-5p ; hsa-mir-6883-5p ; hsa-mir-3175 ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-873-5p ; hsa-mir-1827 ; hsa-mir-637 ; hsa-mir-940 ; hsa-mir-6808-5p ; hsa-mir-6893-5p ; hsa-mir-5585-3p ; hsa-mir-606 ; hsa-mir-616-3p ; hsa-mir-4786-3p ; hsa-mir-4729 ; hsa-mir-4528 ; hsa-mir-4762-3p ; hsa-mir-3192-3p ; hsa-mir-4502
Nearest miRNA
hsa-mir-4645/Upstream/1171161; hsa-mir-10398/Downstream/1122965;
Nearest TSS
ENST00000381078/Upstream/3942; ENST00000490399/Downstream/12151;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/3498, chr6-CpG: 87/Downstream/53550
Upstream sequence
GATATTAAATTGTAAAATGTTAATGTTAAAGCGTAAATTTATATAAATGAAATATATATGGCCTATATTTATTGTCAGTATAAACTATCCAAGAGGGCCG
Downstream sequence
TTAGGTTTCTTAACAAGAAACCTTTTTCTTGAGCTTTAGAAGAAAGTCGTTGATGATAAAGCTAATTTAGCTGTTTTAGCACAGGCCCATTGTATGTAAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate