Basic Information
VIS ID
TVIS44031822
Fusion event
HTLV-1-PRUNE2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
NCBI36/hg18
Start
78593772/76789036 (Hg38)
End
78593772/76789036 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRUNE2
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-196a-5p ; hsa-mir-93-5p ; hsa-mir-19b-3p ; hsa-mir-769-5p ; hsa-mir-382-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-4671-3p ; hsa-mir-593-5p ; hsa-mir-6124 ; hsa-mir-4733-3p ; hsa-mir-3148 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-570-5p ; hsa-mir-548ba ; hsa-mir-548ai ; hsa-mir-548ag ; hsa-mir-4796-3p ; hsa-mir-548m ; hsa-mir-196b-5p ; hsa-mir-301a-3p ; hsa-mir-3666 ; hsa-mir-130a-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-101-2/Upstream/5978952; hsa-let-7a-1/Downstream/7180712;
Nearest TSS
ENST00000422679/Upstream/24532; ENST00000376708/Downstream/80146;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/329391, chr9-CpG: 75/Downstream/116851
Upstream sequence
CCTTGTTAGGAAGAGCAAGTATCATACAAACTCTCAAGGATCCTTCTCTCCCAGGGAAGACTCGTGGGAGGGAGGGCCTAGTAGGAGCTTGAGGTATTTC
Downstream sequence
CTCATAATTTTCTTCAGCCTCCACCCTCATATTTTCAGATGGACAATAGATATGTTTACATTTTTGTGAAAAGTACTTTGCATGCACAGCTTCAAGACAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate