Basic Information
VIS ID
TVIS44031928
Fusion event
HTLV-1-ALMS1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
NCBI36/hg18
Start
73670561/73589926 (Hg38)
End
73670561/73589926 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
ALMS1
miRNAs that regulate target gene
hsa-mir-197-3p ; hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-99b-3p ; hsa-mir-92a-3p ; hsa-mir-22-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/3336921; hsa-mir-10b/Downstream/1500886;
Nearest TSS
ENST00000437798/Upstream/69981; ENST00000464408/Downstream/10909;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/203393, chr2-CpG: 31/Downstream/147265
Upstream sequence
cgtctgtctgaaactgtctttagcatatatacccagaagtggaattcttggcttacaggctcgtatacttaatttcctacattagtaccaaattgctttc
Downstream sequence
cagttcatattcctacctgcagtgcatgaaaatttccatttctacttctctgccaaTTATTTCTAATTTTTATCAGAACACTAGTAAAACAAGTTTCTAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate