Basic Information
VIS ID
TVIS44031958
Fusion event
HTLV-1-CTDSPL integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
NCBI36/hg18
Start
37894975/37878480 (Hg38)
End
37894975/37878480 (Hg38)
Orient
+
Location type
Intronic
Target gene
CTDSPL
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-124-3p ; hsa-mir-183-5p ; hsa-mir-18a-5p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-651-3p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-6830-5p ; hsa-mir-6838-5p ; hsa-mir-99a-5p ; hsa-mir-770-5p ; hsa-mir-500a-3p ; hsa-mir-767-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-186-3p ; hsa-mir-646 ; hsa-mir-503-5p ; hsa-mir-4258 ; hsa-mir-6753-5p ; hsa-mir-1911-3p ; hsa-mir-8485 ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-12127/Upstream/2133921; hsa-let-7g/Downstream/90924;
Nearest TSS
ENST00000440867/Upstream/16302; ENST00000416688/Downstream/66234;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/15932, chr3-CpG: 29/Downstream/115730
Nearest cancer related gene
CTDSPL(TSG, No orient, 0)
Upstream sequence
agtttatttgcatacgtggatgtccagttgtttctgcatcatttattgaaaagaccatcctttcttcattgttttgcctttgaacctttattaaaaatca
Downstream sequence
atgactatatatatgtgtgggcctatttctggattctAATCTCTCCTTAAATTTTGATCGCTTTCCTTACTGTGAAGCAGTGTTAAACTTAGGATAGTAC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate