Basic Information
VIS ID
TVIS44031968
Fusion event
HTLV-1-SLC24A2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr9
Cytoband
p21.3
Reference genome
NCBI36/hg18
Start
20227706/20237708 (Hg38)
End
20227706/20237708 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
SLC24A2
miRNAs that regulate target gene
hsa-mir-1277-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6083 ; hsa-mir-4789-5p ; hsa-mir-4774-5p ; hsa-mir-4490 ; hsa-mir-340-5p ; hsa-mir-142-5p ; hsa-mir-5590-3p ; hsa-mir-4775 ; hsa-mir-29a-5p ; hsa-mir-590-3p ; hsa-mir-410-3p ; hsa-mir-4672 ; hsa-mir-6768-5p ; hsa-mir-519e-5p ; hsa-mir-515-5p ; hsa-mir-4474-5p ; hsa-mir-5695 ; hsa-mir-519d-5p ; hsa-mir-3922-5p ; hsa-mir-3142 ; hsa-mir-1245b-5p
Nearest miRNA
hsa-mir-101-2/Upstream/1664329; hsa-let-7a-1/Downstream/173440;
Nearest TSS
ENST00000422679/Upstream/311614; ENST00000604036/Downstream/125861;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/302879, chr9-CpG: 167/Downstream/382717
Upstream sequence
ATTTCTCTTTTTATGTTTTGCTATTCATGCTCAAGAAAGAGCACTCACCTGGCACTGGGAAGCACTCCGATTTTTTTTTGTTTTTAATGATTCTTAGTAA
Downstream sequence
GACTTGATCTGAGCAGTCTTAATAAAGTGCAGGGGGATAATTCAGGCCTCTGTTGTGGTGGGTTTCTTAGCCCTATCTTCATAGGCAGAGTCCTCCTTGC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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