Basic Information
VIS ID
TVIS44031999
Fusion event
HTLV-1-PBX1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr1
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
162885644/164649783 (Hg38)
End
162885644/164649783 (Hg38)
Orient
+
Location type
Intronic
Target gene
PBX1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-149-5p ; hsa-mir-196b-5p ; hsa-mir-198 ; hsa-mir-1247-3p ; hsa-mir-3074-5p ; hsa-mir-4722-3p ; hsa-mir-617 ; hsa-mir-6505-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6882-3p
Nearest miRNA
hsa-mir-101-1/Upstream/2307143; hsa-mir-1182/Downstream/1258138;
Nearest TSS
ENST00000473358/Upstream/18802; ENST00000559560/Downstream/2113;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/73103, chr1-CpG: 29/Downstream/467736
Nearest cancer related gene
PBX1(OG, No orient, 0)
Upstream sequence
ACTTTCAAGTTAGCTTTTTATTGCATTCCACCCCCTGCCAGGGAGCAAACTTAAACTCATGCAACTCAAAATGACCATGCTGGGTCTGTTCTAAGTTTGA
Downstream sequence
ATTTGGACCTTGATCCAGCCTTCACATACTTTCTCTTATGAATTCCTCTTAATGCTAGTTAATAAAAATATAATGGCTTTCATGTCCCTTCTCATAATAA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate