Basic Information
VIS ID
TVIS44032030
Fusion event
HTLV-1-ZMIZ1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
80671721/79241958 (Hg38)
End
80671721/79241958 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
ZMIZ1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-96-5p ; hsa-mir-93-5p ; hsa-mir-1180-3p ; hsa-mir-1301-3p ; hsa-mir-1185-1-3p ; hsa-mir-1185-2-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-let-7c-3p ; hsa-mir-29b-2-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-8069 ; hsa-mir-134-3p ; hsa-mir-7114-5p ; hsa-mir-493-5p ; hsa-mir-1249-5p ; hsa-mir-331-3p ; hsa-mir-4313 ; hsa-mir-6515-5p ; hsa-mir-6715a-3p ; hsa-mir-6715b-3p ; hsa-mir-6757-5p ; hsa-mir-6797-5p ; hsa-mir-6798-5p ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-874-5p ; hsa-mir-1264 ; hsa-mir-3657 ; hsa-mir-4433a-5p ; hsa-mir-4433b-5p ; hsa-mir-4455 ; hsa-mir-4795-5p ; hsa-mir-609 ; hsa-mir-662 ; hsa-mir-6748-5p ; hsa-mir-6772-5p
Nearest miRNA
hsa-mir-1265/Upstream/3689405; hsa-mir-107/Downstream/7022736;
Nearest TSS
ENST00000439456/Upstream/40363; ENST00000472035/Downstream/1711;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/171500, chr10-CpG: 148/Downstream/320
Upstream sequence
TCAGCTCCCGGTGTTGGCCAGGGCAGCAGGGCACGGCAGTCCAATACAGAGGAGATTTTAAAGACAGTCATGGCTGCCCTTCTTTGGGGATGAATGATGG
Downstream sequence
GGACTCACTTACCTTCCTAAGTGTTTGGGGCAGTTAGGTCACCACACAAGCAACTTTCACAGGCAGGTGGGTGGGGCTGGGGGAGGGAGCTATAAAATAC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate