Basic Information
VIS ID
TVIS44032042
Fusion event
HTLV-1-NDNF integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
q27
Reference genome
NCBI36/hg18
Start
122210582/121069977 (Hg38)
End
122210582/121069977 (Hg38)
Orient
+
Location type
Intronic
Target gene
NDNF
miRNAs that regulate target gene
hsa-mir-4709-3p ; hsa-mir-4635 ; hsa-mir-3185 ; hsa-mir-6507-5p ; hsa-mir-522-3p ; hsa-mir-224-3p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-607 ; hsa-mir-6844 ; hsa-mir-452-3p ; hsa-mir-6715b-3p ; hsa-mir-4670-3p ; hsa-mir-146a-3p ; hsa-mir-4714-5p ; hsa-mir-6826-3p ; hsa-mir-578 ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-6769b-3p ; hsa-mir-4662a-5p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-6892-3p ; hsa-mir-1224-3p ; hsa-mir-6865-3p ; hsa-mir-4694-5p ; hsa-mir-509-3p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-548t-5p ; hsa-mir-550b-3p ; hsa-mir-6507-3p ; hsa-mir-6838-3p
Nearest miRNA
hsa-mir-12113/Upstream/6413123; hsa-mir-1305/Downstream/4437282;
Nearest TSS
ENST00000502981/Upstream/30993; ENST00000507782/Downstream/1452;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/146939, chr4-CpG: 171/Downstream/871
Upstream sequence
TGGGGTATTTTAATATAATCCTGAATATAGGTTTAGATTGAAAATGGGAATTGGGACCATAATTAATTATGTTGCCAAGTTTTTTAAACTTTAAGAAGAC
Downstream sequence
AGATGGAGGCAAATGACATTTTATAAGAGTGCAACCTTCTAAAAGATCATAGATTAAAACTGTGGTAAAACGACAGTATCTTTTTTGACATTTGATTAAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate