Basic Information
VIS ID
TVIS44032119
Fusion event
HTLV-1-VSNL1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p24.2
Reference genome
NCBI36/hg18
Start
17685035/17640287 (Hg38)
End
17685035/17640287 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2C
Target gene
VSNL1
miRNAs that regulate target gene
hsa-mir-181b-5p ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-5585-3p ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-548n ; hsa-mir-6818-5p ; hsa-mir-574-5p ; hsa-mir-6867-5p ; hsa-mir-1257 ; hsa-mir-22-3p ; hsa-mir-5010-3p ; hsa-mir-147a ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-587 ; hsa-mir-8068 ; hsa-mir-5087 ; hsa-mir-520g-5p ; hsa-mir-6873-5p ; hsa-mir-518e-3p ; hsa-mir-1273h-3p ; hsa-mir-2113 ; hsa-mir-3158-5p ; hsa-mir-3166 ; hsa-mir-3672 ; hsa-mir-4461 ; hsa-mir-4494 ; hsa-mir-4499 ; hsa-mir-4771 ; hsa-mir-4790-3p ; hsa-mir-6864-3p ; hsa-mir-873-3p
Nearest miRNA
hsa-mir-3125/Upstream/4902843; hsa-mir-10b/Downstream/1708142;
Nearest TSS
ENST00000437798/Upstream/99127; ENST00000614478/Downstream/41729;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/99533, chr2-CpG: 131/Downstream/113001
Nearest cancer related gene
VSNL1(TSG, No orient, 0)
Upstream sequence
agttacagtgagccaagatcgtgccattgcactctggcctgggcaacagagcgagactctgtttcaaaaaaaaaaaaaaaaagaaagaaaagaaaAgaaa
Downstream sequence
ctaaagctttgaaaagattaaaaatcctttgcccgagaccaggtcccacatgtagtgaactgcagaactgatattcaatcccagacccatccaaccccaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate