Basic Information
VIS ID
TVIS44032136
Fusion event
HTLV-1-ROBO1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
NCBI36/hg18
Start
78958755/78826915 (Hg38)
End
78958755/78826915 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROBO1
miRNAs that regulate target gene
hsa-mir-217 ; hsa-mir-218-5p ; hsa-mir-423-3p ; hsa-mir-25-3p ; hsa-mir-6835-3p ; hsa-mir-146a-5p ; hsa-mir-377-3p ; hsa-mir-1185-2-3p ; hsa-mir-876-3p ; hsa-mir-3591-5p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-636 ; hsa-mir-3140-3p ; hsa-mir-4445-5p ; hsa-mir-508-3p ; hsa-mir-8062 ; hsa-mir-8079 ; hsa-mir-1245a ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-299-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-4782-3p ; hsa-mir-6766-3p ; hsa-mir-219a-5p ; hsa-mir-6885-3p ; hsa-mir-1273e ; hsa-mir-4327 ; hsa-mir-1287-5p ; hsa-mir-3135b ; hsa-mir-330-3p ; hsa-mir-29a-3p ; hsa-mir-218-2-3p
Nearest miRNA
hsa-let-7g/Upstream/3088552; hsa-mir-12124/Downstream/680972;
Nearest TSS
ENST00000440867/Upstream/111658; ENST00000473938/Downstream/191629;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1728667, chr3-CpG: 49/Downstream/191998
Nearest cancer related gene
ROBO1(TSG, No orient, 0)
Upstream sequence
cctccagttgtttttgtattgtgaattgaaacattgggacctcagctgaagtaactttctggtaacacaacctgacagttgatgtttcaaatttggtagc
Downstream sequence
tgccatctttactggacaacaatgtttctatagttgttttaacatatgattttgcatatacatacttatacgtacttaaattttatttatattatataaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate