Basic Information
VIS ID
TVIS44032198
Fusion event
HTLV-1-FHIT integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p14.2
Reference genome
NCBI36/hg18
Start
60716612/60755839 (Hg38)
End
60716612/60755839 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3B
Target gene
FHIT
miRNAs that regulate target gene
hsa-mir-143-3p ; hsa-mir-217 ; hsa-mir-331-3p ; hsa-mir-625-5p
Nearest miRNA
hsa-let-7g/Upstream/137969; hsa-mir-12124/Downstream/6469625;
Nearest TSS
ENST00000440867/Upstream/674999; ENST00000475527/Downstream/495545;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/1705621, chr3-CpG: 48/Downstream/495093
Nearest cancer related gene
FHIT(TSG, No orient, 0)
Upstream sequence
ATTTAGAAATTTAGAGACATTGGTTAAATAAGTTAAGGAACAATGAGccagactctgaagtcccagcaaggagggactgtatctttgttttattcagtac
Downstream sequence
ctatcaagagtgctaagtacaCAGGTTTGAATGGAACTGATTTGAATCATTTAAGGAAAAAGGTTCCAGACAAACATTGCATGCATTAGAAACTGAGTAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate