Basic Information
VIS ID
TVIS44032208
Fusion event
HTLV-1-ARL15 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q11.2
Reference genome
NCBI36/hg18
Start
53252920/53921333 (Hg38)
End
53252920/53921333 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5H
Target gene
ARL15
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-7-5p ; hsa-mir-222-5p ; hsa-mir-3177-5p ; hsa-mir-7110-3p ; hsa-mir-4797-3p ; hsa-mir-4264 ; hsa-mir-936 ; hsa-mir-648 ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-3129-5p ; hsa-mir-6873-3p ; hsa-mir-6817-3p
Nearest miRNA
hsa-mir-10397/Upstream/15363772; hsa-mir-103a-1/Downstream/30171;
Nearest TSS
ENST00000502646/Upstream/40282; ENST00000512618/Downstream/389082;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/360293, chr5-CpG: 59/Downstream/388769
Upstream sequence
ttgttcaagagcaagcagctaacaggtgaagaaactgacattctgcccttggtcagtgaaactttaggacccatgttcttacctatgggtatactgtccc
Downstream sequence
ccCTATAGCTATTGTAAGTATGTAAGTACAAAAACCTATGTGTTAGACATTTCCCCTTTTAACCTTGAACTTATGTTCCAGTAATAGAAACATTTTATTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate