Basic Information
VIS ID
TVIS44032214
Fusion event
HTLV-1-EXOC6B integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
p13.2
Reference genome
NCBI36/hg18
Start
72287332/72206695 (Hg38)
End
72287332/72206695 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
EXOC6B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-25-3p ; hsa-mir-7977 ; hsa-mir-6516-3p ; hsa-mir-6849-3p ; hsa-mir-5588-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/1953690; hsa-mir-10b/Downstream/2884117;
Nearest TSS
ENST00000437798/Upstream/58657; ENST00000498749/Downstream/56742;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/56649, chr2-CpG: 63/Downstream/618813
Upstream sequence
CCCAAGTGTTTTATGCTTATATCTCCCAGAATAGAATGTCAACTCTTTGAGCAAGGGACACACAGTAGAACCTCAACATACTGTGACTAAACTCCACAGA
Downstream sequence
GACTAACAAAAAGCTCTTGATGTATTAAataaggatacactttataataaagagagttgttcattagtggaatgtgctgGAACAGAATGAGTGAAATGTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate