Basic Information
VIS ID
TVIS44032237
Fusion event
HTLV-1-RPS6KA6 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chrX
Cytoband
q21.1
Reference genome
NCBI36/hg18
Start
83290217/84148553 (Hg38)
End
83290217/84148553 (Hg38)
Orient
+
Location type
Intronic
Target gene
RPS6KA6
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-192-3p ; hsa-mir-129-5p ; hsa-mir-2113 ; hsa-mir-4687-3p ; hsa-mir-5010-3p ; hsa-mir-627-3p ; hsa-mir-758-3p ; hsa-mir-7974 ; hsa-mir-889-5p
Nearest miRNA
hsa-let-7f-2/Upstream/5247304; hsa-mir-105-1/Downstream/77199;
Nearest TSS
ENST00000429181/Upstream/42092; ENST00000373173/Downstream/37588;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/637785, chrX-CpG: 95/Downstream/38835
Nearest cancer related gene
RPS6KA6(TSG, No orient, 0)
Upstream sequence
TTCTTAGATTTAATTTAGTTTTTAATCAAAAAAACTGTTATGATTTAATAAATCATAATGCATATAAATACTACTATAGAAAGGAAAATTTTTAAAATAG
Downstream sequence
ATGACCTGGTACTGAACTTTGAGAATTTTGTGATGTAAGAGATAAATAACATAATGAAAGACAAACTTGAGCTACATACCTCCTTTTAAGACCCAGGCCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate