Basic Information
VIS ID
TVIS44032238
Fusion event
HTLV-1-ARHGAP6 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chrX
Cytoband
p22.2
Reference genome
NCBI36/hg18
Start
11592026/11663985 (Hg38)
End
11592026/11663985 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP6
miRNAs that regulate target gene
hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-374b-5p ; hsa-mir-374a-5p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-5088-3p ; hsa-mir-5692c ; hsa-mir-5692b ; hsa-mir-369-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/345299; hsa-let-7f-2/Downstream/1926307;
Nearest TSS
ENST00000429181/Upstream/236212; ENST00000478462/Downstream/1098;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/235923, chrX-CpG: 166/Downstream/228
Upstream sequence
ACAGCTTAGCAATAGATATTTGAGTTGGAAAAAATATCAACATTGGGTGAAGGGATAAGGTGACCCTTTGAAATTGCCTGCAGCACTAACAGAAAACCAG
Downstream sequence
AACACCATCTCTTTCTCCAGCTCCCACGACTGCTCCAAAGTAGAGCCAACAAGTCCTACAAGACGCACAAGCGGGTGGCCACTAGGGACATCCCATTTCC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate