Basic Information
VIS ID
TVIS44032270
Fusion event
HTLV-1-WDR91 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
NCBI36/hg18
Start
134537975/135202683 (Hg38)
End
134537975/135202683 (Hg38)
Orient
-
Location type
Intronic
Target gene
WDR91
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-6848-3p ; hsa-mir-6843-3p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-4755-3p ; hsa-mir-6131 ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-4781-3p ; hsa-mir-378a-5p ; hsa-mir-3155a ; hsa-mir-3155b ; hsa-mir-3923 ; hsa-mir-484 ; hsa-mir-554 ; hsa-mir-6815-3p
Nearest miRNA
hsa-mir-10525/Upstream/1911695; hsa-mir-10399/Downstream/4311;
Nearest TSS
ENST00000635602/Upstream/3075; ENST00000275764/Downstream/4465;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/31739, chr7-CpG: 67/Downstream/8579
Upstream sequence
CACACAGTTCCTAACCACATAGAGTAGGGCCACAGCTTACTCCCACAGAAGCTGTCTCTATGTTTTCTTTCAAGTTAATGAAATTGAATTCCATAATTTC
Downstream sequence
AAGCTCATTTCAAAGGACTCAACATTCCACACATCACCTATTAAACTTATAAAATGTTGCACAGTGAGAGATCCAGAAAGCAAGCAGTACAACTTACTCG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate