Basic Information
VIS ID
TVIS44032284
Fusion event
HTLV-1-FOXA2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr20
Cytoband
p11.21
Reference genome
NCBI36/hg18
Start
22511783/22583145 (Hg38)
End
22511783/22583145 (Hg38)
Orient
+
Location type
Intronic
Target gene
FOXA2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-mir-187-3p ; hsa-mir-124-3p ; hsa-mir-200a-3p ; hsa-mir-199a-3p ; hsa-mir-1290 ; hsa-mir-3167 ; hsa-mir-450a-1-3p ; hsa-mir-5096 ; hsa-mir-6716-5p ; hsa-mir-876-5p
Nearest miRNA
hsa-mir-103a-2/Upstream/4112454; hsa-mir-1-1/Downstream/3625041;
Nearest TSS
ENST00000382410/Upstream/4503; ENST00000635173/Downstream/1116;
Nearest CpG islands
chr20-CpG: 262/Target, None/Upstream, None/Downstream
Nearest cancer related gene
FOXA2(TSG, No orient, 0)
Upstream sequence
CGCTCATGTTGCCCGAGCCGCTGCCCATGGCGGCCGCCGACATGCTCATGTACGTGTTCATGCCGTTCATCCCCAGGCCGGCGTTCATGTTGCTCACGGA
Downstream sequence
GGAGTAGCCCTGCGGACAGAGCCCCGGGAGGGAGGCGACAGCGTTAGCACCGCGGCTGGAGGGTGCCCAGACCTCCCACCCACCGCCCAGGCCTCCGCGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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