Basic Information
VIS ID
TVIS44032292
Fusion event
HTLV-1-GABRB3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q12
Reference genome
NCBI36/hg18
Start
24434778/26638538 (Hg38)
End
24434778/26638538 (Hg38)
Orient
-
Location type
Intronic
Target gene
GABRB3
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-125b-5p ; hsa-let-7g-3p ; hsa-let-7a-2-3p ; hsa-mir-3177-5p ; hsa-mir-3163 ; hsa-mir-5582-3p ; hsa-mir-552-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-3678-3p ; hsa-mir-1273h-3p ; hsa-mir-6802-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-298 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-4691-3p ; hsa-mir-497-3p ; hsa-mir-424-3p ; hsa-mir-4703-3p ; hsa-mir-520d-5p ; hsa-mir-524-5p
Nearest miRNA
hsa-mir-1268a/Upstream/789713; hsa-mir-10393/Downstream/1787953;
Nearest TSS
ENST00000557528/Upstream/9360; ENST00000555060/Downstream/20225;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/9157, chr15-CpG: 52/Downstream/31504
Upstream sequence
tccttcctctcttccaaggtgatctcaatcattcctaagatgtttgacaaaaaccatagctgatgacacccatttctggctgaaggccggagacccctct
Downstream sequence
gagtgccaatcccttatccagctgctcttctgacagcactactttgtagtctctttgtcatctTTATTCCTTCTCTTTCCTTGTTTCCTAATCCAGTTcc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate