Basic Information
VIS ID
TVIS44032363
Fusion event
HTLV-1-TBL2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q11.23
Reference genome
NCBI36/hg18
Start
72629607/73577341 (Hg38)
End
72629607/73577341 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
TBL2
miRNAs that regulate target gene
hsa-mir-6736-3p ; hsa-mir-483-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-4279 ; hsa-mir-7111-3p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-3926 ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-548c-3p ; hsa-mir-4684-5p ; hsa-mir-665 ; hsa-mir-4443 ; hsa-mir-6514-3p ; hsa-mir-516b-5p ; hsa-mir-7977 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6811-3p ; hsa-mir-214-5p ; hsa-mir-5589-3p ; hsa-mir-518c-5p ; hsa-mir-5690 ; hsa-mir-3664-5p ; hsa-mir-514a-5p ; hsa-mir-4714-5p ; hsa-mir-5193 ; hsa-mir-660-3p ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-4695-5p
Nearest miRNA
hsa-mir-1183/Upstream/879363; hsa-mir-10399/Downstream/133976;
Nearest TSS
ENST00000635602/Upstream/593; ENST00000324941/Downstream/928;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/6463, chr7-CpG: 95/Downstream/763
Nearest cancer related gene
TBL2(TSG, No orient, 0)
Upstream sequence
agagcaaaactccgtccccctgcaaaaaaaaaaaaaaaaaaaaTGCAGGGCTggccgggcacagtggttcacgcctgtaatctcagcacttttggaggcc
Downstream sequence
aggacgagtggatcacctgagatcaggcgttcgagaccagcctgaccaacgtggcgaaaccccgtctactaaatatacaaaaattagccaggcgtggtgg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate