Basic Information
VIS ID
TVIS44032406
Fusion event
HTLV-1-DROSHA integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
NCBI36/hg18
Start
31467809/31431945 (Hg38)
End
31467809/31431945 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
DROSHA
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-760 ; hsa-mir-505-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-4290 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6892-3p ; hsa-mir-6872-3p ; hsa-mir-8485 ; hsa-mir-4762-5p ; hsa-mir-216a-5p ; hsa-mir-6516-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-4660 ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-148a-5p
Nearest miRNA
hsa-mir-10397/Upstream/14275953; hsa-mir-103a-1/Downstream/504157;
Nearest TSS
ENST00000502646/Upstream/2412; ENST00000515409/Downstream/5379;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/237633, chr5-CpG: 42/Downstream/100058
Upstream sequence
GTCCTATACATACAGCTCAGTTTTCACTAACTCAATTCTTTCCCAAACAGGCTTCTACAAACTCCAATAGTTCAAGTAGGGTTCAGAATTGATCAGATCT
Downstream sequence
GAACTTTCCAATTCCAAGTTCAGATCAAGCACTAGCCCAGGCTGGAATAAGACTCTGCTACAAGCCCCTGGGTTCATCCAATATGCCTAGGGAGAGAATT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate