VISDB - VIS Detail

Basic Information

VIS ID

TVIS44032421

Fusion event

HTLV-1-AQP3 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr9

Cytoband

p13.3

Reference genome

NCBI36/hg18

Start

33432877/33442879 (Hg38)

End

33432877/33442879 (Hg38)

Orient

Location type

Intronic

Target gene

AQP3

miRNAs that regulate target gene

hsa-mir-615-3p ; hsa-mir-874-3p ; hsa-mir-185-5p ; hsa-mir-6882-3p ; hsa-mir-4641 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-4789-3p ; hsa-mir-8485 ; hsa-mir-4643 ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-653-5p ; hsa-mir-6869-5p ; hsa-mir-877-5p ; hsa-mir-889-3p ; hsa-mir-3163 ; hsa-mir-3159 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-1277-5p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n

Nearest miRNA

hsa-mir-101-2/Upstream/334114; hsa-let-7a-1/Downstream/24990;

Nearest TSS

ENST00000422679/Upstream/40022; ENST00000496561/Downstream/230;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/151874, chr9-CpG: 41/Downstream/4569

Upstream sequence

CAACCAGCCCATGAGCTACCAAGGCAACTCGGTCCCCTCCCTGCGTTCCCCTCACACGTCCCCAGCCCATACCTGGTCAAAGAAGCCATTGATCATATCC

Downstream sequence

AAGTGTCCAGAGGGGTAGGTAGCAAAGATGCCGGCTGTGCCATTGGGGCCCGAAACAAAAAGCTGGTTGTCGGCGAAGTGCCAGATTGCATCTGGTGACA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.