Basic Information
VIS ID
TVIS44032426
Fusion event
HTLV-1-MAP3K3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr17
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
59077732/63646640 (Hg38)
End
59077732/63646640 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAP3K3
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-9-5p ; hsa-mir-132-3p ; hsa-mir-124-3p ; hsa-mir-193b-3p ; hsa-mir-181a-5p ; hsa-mir-188-5p ; hsa-mir-19a-5p ; hsa-mir-19b-1-5p ; hsa-mir-19b-2-5p ; hsa-mir-96-5p ; hsa-mir-1271-5p ; hsa-mir-1178-5p ; hsa-mir-1182 ; hsa-mir-4328 ; hsa-mir-3613-3p ; hsa-mir-6753-3p ; hsa-mir-6885-3p ; hsa-mir-7107-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-181d-5p ; hsa-mir-519d-3p ; hsa-mir-2052 ; hsa-mir-3140-3p ; hsa-mir-140-3p ; hsa-mir-182-5p ; hsa-mir-183-5p ; hsa-mir-193a-3p ; hsa-mir-328-5p ; hsa-mir-4459 ; hsa-mir-4754 ; hsa-mir-4779 ; hsa-mir-6774-5p ; hsa-mir-6804-5p ; hsa-mir-759 ; hsa-mir-3119 ; hsa-mir-892b
Nearest miRNA
hsa-mir-10226/Upstream/702328; hsa-mir-1250/Downstream/854134;
Nearest TSS
ENST00000595228/Upstream/23930; ENST00000585302/Downstream/20346;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/23272, chr17-CpG: 221/Downstream/52890
Upstream sequence
ATGGGAAGCTGCACCAAGTCCATCAGTTGTAAAAGACTTTAGCTCCTTTGAGGACATAGAAAGAGGGAGTTTTTCGGTCTGTGTTCTGAATCTTACCTCA
Downstream sequence
TTAGGGAAGTGAAAGTAGTGTTACAAAACTCTTCTGTCCTTTTCTCCATTGTCAGTATTTTCATTATTGTTATTTTTTGTGGGAAGCCAAGGTAGAAGTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate