Basic Information
VIS ID
TVIS44032442
Fusion event
HTLV-1-NLN integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
NCBI36/hg18
Start
65066165/65734582 (Hg38)
End
65066165/65734582 (Hg38)
Orient
+
Location type
Intronic
Target gene
NLN
miRNAs that regulate target gene
hsa-mir-16-1-3p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-144-3p ; hsa-mir-370-5p ; hsa-mir-374a-5p ; hsa-mir-374b-5p ; hsa-mir-627-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-3681-3p ; hsa-mir-7152-5p ; hsa-mir-3074-5p ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-3926 ; hsa-mir-5189-3p ; hsa-mir-548av-3p ; hsa-mir-5582-3p ; hsa-mir-548f-3p ; hsa-mir-548e-3p ; hsa-mir-548az-3p ; hsa-mir-548ar-3p ; hsa-mir-548a-3p ; hsa-mir-6507-3p ; hsa-mir-7856-5p ; hsa-mir-3658 ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p ; hsa-mir-593-3p ; hsa-mir-6879-3p ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p ; hsa-mir-1182 ; hsa-mir-4524b-3p ; hsa-mir-641 ; hsa-mir-3617-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-4713-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6845-3p ; hsa-mir-2116-3p ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-193a-5p
Nearest miRNA
hsa-mir-10397/Upstream/6030879; hsa-mir-103a-1/Downstream/6434885;
Nearest TSS
ENST00000502646/Upstream/11547; ENST00000506677/Downstream/42835;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/11897, chr5-CpG: 158/Downstream/190349
Upstream sequence
GAGTTACCCTCGCACGGATGGTTATTTAAAAATGTCAAAAATAAATGGAACCTGAATGGAAAAAAAAAAAAAGAAAGACTCTGCCCATTCTGCCCACTCT
Downstream sequence
GAGATTGTCTATGCTTCCTGTTTGGCATTCAAGAGGAAGTCCTCATATTTCCCAGCCATATTTTGCTGGTATCTTTAATATTTAATCCCACTTGTGGTCA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate