Basic Information
VIS ID
TVIS44032461
Fusion event
HTLV-1-TBC1D4 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr13
Cytoband
q22.2
Reference genome
NCBI36/hg18
Start
74766773/75294636 (Hg38)
End
74766773/75294636 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA13E
Target gene
TBC1D4
miRNAs that regulate target gene
hsa-mir-98-5p ; hsa-mir-30a-5p ; hsa-mir-19b-3p ; hsa-mir-29b-2-5p ; hsa-mir-7150 ; hsa-mir-4736 ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-1193 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-8069 ; hsa-mir-4456 ; hsa-mir-4494 ; hsa-mir-4463
Nearest miRNA
hsa-mir-1297/Upstream/9076312; hsa-mir-1267/Downstream/2403376;
Nearest TSS
ENST00000623511/Upstream/44156; ENST00000471792/Downstream/8185;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/1158955, chr13-CpG: 197/Downstream/186080
Upstream sequence
ACACAGTCTGTCCCTAGTCCAGATTTTAGGAGTATACTCTCTGATTTTTAGGCACAAATGAAAATAAGAGCTCCATTACAGCTGACTCAAATACAGGAGC
Downstream sequence
CCAATTCCTCTTTCCTTTTTAATTTCAATTTTATGTAAGACAAGTATGATTTTAAGTTACTGTCAGAACACAGCCAGGCACATTTATTAAATTCCATTAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate