Basic Information
VIS ID
TVIS44032464
Fusion event
HTLV-1-RBMS3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
p24.1
Reference genome
NCBI36/hg18
Start
29329561/29313066 (Hg38)
End
29329561/29313066 (Hg38)
Orient
+
Location type
Intronic
Target gene
RBMS3
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-3190-3p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4282 ; hsa-mir-3674 ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-516b-5p ; hsa-mir-1299 ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4703-3p ; hsa-mir-5093 ; hsa-mir-3182 ; hsa-mir-6128 ; hsa-mir-875-3p ; hsa-mir-877-3p ; hsa-mir-1324
Nearest miRNA
hsa-mir-12127/Upstream/3648127; hsa-let-7g/Downstream/1848638;
Nearest TSS
ENST00000440867/Upstream/22340; ENST00000478716/Downstream/121791;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/736587, chr3-CpG: 88/Downstream/1293429
Nearest cancer related gene
RBMS3(TSG, No orient, 0)
Upstream sequence
TCAGGACAGAGGCATGGAGAAGGATGAGAGAGTCTGCCTTGTCTCAAGCCCTAAGCAAATAATCTTTGCATTTCTCCATCCCTACTTGGAAGGCATATTC
Downstream sequence
TTACCATCTGTGGATCATATAATGAATGACTTTTTTGAAGGAATGTTCACATTTCTTATCTTGCTTGTTATACACATCATTTTTCAAACCTTGGAACGAT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate