Basic Information
VIS ID
TVIS44032470
Fusion event
HTLV-1-APBB2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
NCBI36/hg18
Start
40626537/40929763 (Hg38)
End
40626537/40929763 (Hg38)
Orient
-
Location type
Intronic
Target gene
APBB2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p ; hsa-mir-9-5p ; hsa-mir-26b-5p ; hsa-mir-424-5p ; hsa-mir-93-5p ; hsa-mir-27a-3p ; hsa-mir-1260b ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-3915 ; hsa-mir-526b-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-3116 ; hsa-mir-1254 ; hsa-mir-3663-3p ; hsa-mir-4638-3p ; hsa-mir-3690 ; hsa-mir-942-3p
Nearest miRNA
hsa-mir-12113/Upstream/427644; hsa-mir-1243/Downstream/6722906;
Nearest TSS
ENST00000502981/Upstream/36491; ENST00000514924/Downstream/4724;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/72473, chr4-CpG: 95/Downstream/284091
Upstream sequence
ACAAATGACAAAGCCTAGAGTGAACTGATacgtggacaaagaggagtactctaggatattactgatgggattatatgctgctgcaggctttctggaaagt
Downstream sequence
aattttgcaataagtgacagaagcaataaaaccgatagcctttgccccagtaataccagttttagcaacctataccaaagcaataatttaaaaGAAAAAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate