Basic Information
VIS ID
TVIS44032474
Fusion event
HTLV-1-SART3 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q23.3
Reference genome
NCBI36/hg18
Start
107470498/108552592 (Hg38)
End
107470498/108552592 (Hg38)
Orient
-
Location type
Intronic
Target gene
SART3
miRNAs that regulate target gene
hsa-mir-378a-5p ; hsa-let-7g-5p ; hsa-mir-92a-3p ; hsa-let-7f-5p ; hsa-mir-3189-5p ; hsa-mir-5692b ; hsa-mir-5692c ; hsa-mir-3163 ; hsa-mir-4323 ; hsa-mir-6856-3p ; hsa-mir-4789-3p ; hsa-mir-1277-5p ; hsa-mir-548c-3p ; hsa-mir-10b-5p ; hsa-mir-124-3p ; hsa-mir-1233-5p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-30b-3p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-3714 ; hsa-mir-3910 ; hsa-mir-4640-5p ; hsa-mir-4726-5p ; hsa-mir-4728-5p ; hsa-mir-506-3p ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-5585-5p ; hsa-mir-5586-3p ; hsa-mir-6778-5p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-759
Nearest miRNA
hsa-let-7i/Upstream/3960876; hsa-mir-1178/Downstream/83218;
Nearest TSS
ENST00000382841/Upstream/3264; ENST00000544493/Downstream/1606;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/36894, chr12-CpG: 44/Downstream/8127
Nearest cancer related gene
SART3(OG, No orient, 0)
Upstream sequence
aaatagtgaactgagcaaggtcacagaatataagataaacatacaaaaacaaaaaaaaaaacaaaagaacatgtggaaaccaaatttaaagacatagcac
Downstream sequence
catttacaatcactccaaaaaacctaaataattaggtgtatatttaaaaagtttacaaaatctgtatgctgaaaattacaaaatgctgaggaaagaaatc
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate