Basic Information
VIS ID
TVIS44032489
Fusion event
HTLV-1-TSC22D1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
NCBI36/hg18
Start
44017540/44545404 (Hg38)
End
44017540/44545404 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSC22D1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-9-3p ; hsa-mir-590-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p
Nearest miRNA
hsa-mir-2276/Upstream/349204; hsa-mir-1267/Downstream/5451011;
Nearest TSS
ENST00000623511/Upstream/5371; ENST00000617014/Downstream/27941;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/108145, chr13-CpG: 216/Downstream/30525
Nearest cancer related gene
TSC22D1(TSG, No orient, 0)
Upstream sequence
agcctgggcaacaagcgagattctgtctcaaaaaataaataaataaataaaGCTTAAATTTGCCACTGACTCCTTAAAGTGAAAAAGGCTAGTATATGTC
Downstream sequence
ATTAAAAAAACCTTAGTAATTTTAAGAAGATCTCTAAATTGCTCTAACAAATACTTTTTTCATAATTAACCTATCCATTACTTTTACCTCGCTAGTGTCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate