Basic Information
VIS ID
TVIS44032495
Fusion event
HTLV-1-CNTNAP2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
NCBI36/hg18
Start
147374649/148046624 (Hg38)
End
147374649/148046624 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7I
Target gene
CNTNAP2
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-99b-5p ; hsa-mir-4444 ; hsa-mir-6079 ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-4428 ; hsa-mir-571 ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-10399/Upstream/668503; hsa-mir-153-2/Downstream/3191797;
Nearest TSS
ENST00000635602/Upstream/2032; ENST00000636988/Downstream/9849;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1929632, chr7-CpG: 33/Downstream/292778
Nearest cancer related gene
CNTNAP2(TSG, No orient, 0)
Upstream sequence
ACTATCTGTTTTCCGAGTTAGACTTCCACTTTTCCTCTCTGGCTACCTGACACCCCAAGCTAGTGTAGGTGGCTATATCATTGCCTGGAATTGAAGTTTT
Downstream sequence
TAAGCCTCTGATAATTCAGTCTGTAGAAGCTACCCAGCTCAAGAACAAAGGGGAAATTACATATTTCATAACATGCTTCAACATGAATGCATTTAATTAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate