Basic Information
VIS ID
TVIS44032504
Fusion event
HTLV-1-CDK14 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
NCBI36/hg18
Start
90115099/90647849 (Hg38)
End
90115099/90647849 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDK14
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-376c-3p ; hsa-mir-493-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6783-5p ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4428
Nearest miRNA
hsa-mir-10525/Upstream/14732580; hsa-mir-10399/Downstream/1556166;
Nearest TSS
ENST00000635602/Upstream/50496; ENST00000496279/Downstream/61402;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/50799, chr7-CpG: 255/Downstream/616429
Nearest cancer related gene
CDK14(OG, No orient, 0)
Upstream sequence
ggaggctgaggctggatgatcacttgagcccaggagttcgaggctgcagtgagctatggttgcaccactgcactccagcctggacaacagagtgagatcc
Downstream sequence
tgtattaaaaaaatagataagaaaTAAATACATGACATTTATGAAGCTAGAAGATTGTTTCAGGTCCAGTCAGGGGATCAGGAGCAATGCATGTTTACTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate