VISDB - VIS Detail

Basic Information

VIS ID

TVIS44032518

Fusion event

HTLV-1-PPP2R2A integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr8

Cytoband

p21.2

Reference genome

NCBI36/hg18

Start

26280607/26367174 (Hg38)

End

26280607/26367174 (Hg38)

Orient

Location type

Intronic

Target gene

PPP2R2A

miRNAs that regulate target gene

hsa-mir-31-5p ; hsa-mir-222-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-409-3p ; hsa-mir-551b-5p ; hsa-mir-605-3p ; hsa-mir-3910 ; hsa-mir-4796-3p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-218-5p ; hsa-mir-187-5p ; hsa-mir-154-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-556-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-1249-5p ; hsa-mir-1343-5p ; hsa-mir-143-3p ; hsa-mir-221-3p ; hsa-mir-3179 ; hsa-mir-363-5p ; hsa-mir-4274 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4770 ; hsa-mir-5197-3p ; hsa-mir-548ao-3p ; hsa-mir-548v ; hsa-mir-555 ; hsa-mir-6081 ; hsa-mir-6088 ; hsa-mir-6515-5p ; hsa-mir-665 ; hsa-mir-6745 ; hsa-mir-6797-5p ; hsa-mir-6805-5p ; hsa-mir-6809-5p ; hsa-mir-6864-5p ; hsa-mir-6880-5p ; hsa-mir-7515 ; hsa-mir-766-5p ; hsa-mir-7847-3p ; hsa-mir-939-5p

Nearest miRNA

hsa-mir-124-1/Upstream/1021700; hsa-mir-10400/Downstream/681679;

Nearest TSS

ENST00000518652/Upstream/2076; ENST00000520409/Downstream/15724;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/176593, chr8-CpG: 103/Downstream/15600

Upstream sequence

ATCAGAGATACTTCAACAACAGTTTTATCACAGAGCTTAATATGATTCCGATTTCATGGTGTTGTGTGTTACAGAGGATAATAGAACTTATAGAATGTTT

Downstream sequence

TCTTTCATCTGGCTTTTAAAATTATCTGATTTTTGACATAAGGACTAGTAAACCTAGAGTTCTGTTAATAGCAAACATTGCCTTTGAGTGCTACTACTAA

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.