Basic Information
VIS ID
TVIS44032546
Fusion event
HTLV-1-PRDM10 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q24.3
Reference genome
NCBI36/hg18
Start
129305805/129930700 (Hg38)
End
129305805/129930700 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRDM10
miRNAs that regulate target gene
hsa-mir-548c-3p ; hsa-mir-3185 ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-6826-5p ; hsa-mir-513c-3p ; hsa-mir-513a-3p ; hsa-mir-3606-3p ; hsa-mir-4282 ; hsa-mir-6809-3p ; hsa-mir-4776-3p ; hsa-mir-607 ; hsa-mir-4659b-5p ; hsa-mir-4659a-5p ; hsa-mir-5590-5p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-3671 ; hsa-mir-676-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-4762-5p ; hsa-mir-7850-5p ; hsa-mir-1305 ; hsa-mir-374b-3p ; hsa-mir-505-3p ; hsa-mir-5191 ; hsa-mir-1250-3p ; hsa-mir-194-3p ; hsa-mir-1182 ; hsa-mir-1178-5p ; hsa-mir-6833-3p ; hsa-mir-4768-5p
Nearest miRNA
hsa-let-7a-2/Upstream/1408251; hsa-mir-4697/Downstream/736035;
Nearest TSS
ENST00000527297/Upstream/35110; ENST00000530583/Downstream/11890;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34978, chr11-CpG: 119/Downstream/71527
Nearest cancer related gene
PRDM10(OG, No orient, 0)
Upstream sequence
GGAAGCTGTAGATAAGCACATTTAGTTACCCAAAATCAACTTGAGAGCTATGATTAGGCACAAATTAGCCTGGTTTAAAATATAAATGATTATTATAACT
Downstream sequence
AAATGTACTTATTTCTCCACTTCCAATCTGTGAATTGAGGGATGCAGAGAGCTAGTCCAGGAGCTGCCAACCTCTAGGCCTCTGTGTCGTCACTAAATTG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate