Basic Information
VIS ID
TVIS44032565
Fusion event
HTLV-1-MGMT integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
NCBI36/hg18
Start
131168240/129479986 (Hg38)
End
131168240/129479986 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
MGMT
miRNAs that regulate target gene
hsa-mir-181d-5p ; hsa-mir-221-3p ; hsa-mir-222-3p ; hsa-mir-648 ; hsa-mir-767-3p ; hsa-mir-370-3p ; hsa-mir-661 ; hsa-mir-409-3p ; hsa-mir-124-3p ; hsa-mir-127-3p
Nearest miRNA
hsa-mir-107/Upstream/3660164; hsa-mir-202/Downstream/363313;
Nearest TSS
ENST00000439456/Upstream/12724; ENST00000462672/Downstream/221192;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/12540, chr10-CpG: 25/Downstream/299200
Upstream sequence
atgagggatcccaaagagattacctgagttatatattaataccccattagaaattagcagtgagaaattttaaaatattgattcatttagacaataaacc
Downstream sequence
tattagctttttgcataaataacattttaaaataaaaactagctatattttccataaaaaccaattagggaggaatgttatcagtttccattttttaaaa
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate