Basic Information
VIS ID
TVIS44032568
Fusion event
HTLV-1-GRM5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
q14.3
Reference genome
NCBI36/hg18
Start
88165632/88792816 (Hg38)
End
88165632/88792816 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRM5
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-510-3p ; hsa-mir-6815-3p ; hsa-mir-513b-5p ; hsa-mir-4719 ; hsa-mir-892b ; hsa-mir-582-3p ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-548n
Nearest miRNA
hsa-mir-10392/Upstream/616223; hsa-let-7a-2/Downstream/1762958;
Nearest TSS
ENST00000527297/Upstream/281068; ENST00000526139/Downstream/254554;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/283422, chr11-CpG: 40/Downstream/272965
Upstream sequence
TGAAAACTATAAGACATGGTTCTGAGGTGAAATACTGCTTTTTAAATTGTCTTTTCTTAAACCAATTATTAGTGTTTTTTTAATGAAATTATACCATAAC
Downstream sequence
CATTTGTATTTACATACGCTTAGAATATGTGCAAGTATTATTGAAAAATATTTAAAAATTACAAAGTTTTAAACATGTAAGATGGGCCTTGTGGCCCATG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate