Basic Information
VIS ID
TVIS44032586
Fusion event
HTLV-1-ATP6V0A2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr12
Cytoband
q24.31
Reference genome
NCBI36/hg18
Start
122781140/123730640 (Hg38)
End
122781140/123730640 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
ATP6V0A2
miRNAs that regulate target gene
hsa-mir-6721-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-4722-5p ; hsa-mir-2467-3p ; hsa-mir-1827 ; hsa-mir-219b-3p ; hsa-mir-302a-5p ; hsa-mir-6840-3p ; hsa-mir-4459 ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-4761-3p ; hsa-mir-7843-5p ; hsa-mir-6879-5p ; hsa-mir-6735-5p ; hsa-mir-4632-5p ; hsa-mir-4436b-3p ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-302f ; hsa-mir-6771-3p ; hsa-mir-4754 ; hsa-mir-1183 ; hsa-mir-3678-3p ; hsa-mir-7977 ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-6895-5p ; hsa-mir-3158-5p ; hsa-mir-1283 ; hsa-mir-3130-3p ; hsa-mir-3190-5p ; hsa-mir-3613-3p ; hsa-mir-3614-5p ; hsa-mir-3675-3p ; hsa-mir-377-5p ; hsa-mir-3926 ; hsa-mir-4257 ; hsa-mir-4537 ; hsa-mir-455-3p ; hsa-mir-4786-5p ; hsa-mir-548s ; hsa-mir-6086 ; hsa-mir-6499-3p ; hsa-mir-6500-3p ; hsa-mir-6516-5p ; hsa-mir-6801-5p ; hsa-mir-6849-3p ; hsa-mir-873-3p
Nearest miRNA
hsa-let-7i/Upstream/194106; hsa-mir-3612/Downstream/606541;
Nearest TSS
ENST00000382841/Upstream/7430; ENST00000545059/Downstream/2;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/17680, chr12-CpG: 85/Downstream/31337
Upstream sequence
TCTACTTTTTTGTGGCTTTTGTAACTGCCAGTGACCATCGTTAATTATCCTTCAGTTGTGACCTTGATGACTTTTCTATTTCAAGCTGATGATTAAAACT
Downstream sequence
AAGATCAAAACTGTTCTGAAGTAGCATTTACATATTTTTTGAGTTTTTTCTTTATTAAGAGAAAATATCAGTAATTCTCATGCGAGCATTTACTCAAGTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate