Basic Information
VIS ID
TVIS44032608
Fusion event
HTLV-1-LRRC20 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
71805425/70375663 (Hg38)
End
71805425/70375663 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
LRRC20
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-484 ; hsa-mir-6760-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-1224-5p ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-6799-5p ; hsa-mir-3935 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-6770-5p ; hsa-mir-544b ; hsa-mir-140-3p ; hsa-mir-6831-5p ; hsa-mir-1245b-3p ; hsa-mir-3927-3p ; hsa-mir-5683 ; hsa-let-7b-5p ; hsa-mir-98-5p ; hsa-let-7a-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-let-7i-5p ; hsa-let-7e-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7f-5p ; hsa-let-7g-5p ; hsa-mir-4522 ; hsa-mir-20a-3p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-210-5p ; hsa-mir-4749-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-22-3p ; hsa-mir-6768-3p
Nearest miRNA
hsa-mir-1265/Upstream/2972253; hsa-mir-107/Downstream/1415084;
Nearest TSS
ENST00000439456/Upstream/91987; ENST00000373218/Downstream/1116;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/91533, chr10-CpG: 108/Downstream/6141
Upstream sequence
AGACAGACAGACACACACACACACACACCCCTACCTGCCTGTGAAATTCCTCTCCATGTACCTAACTCCAATTCTGCCTGCCTATCTGCAAGATCATCCC
Downstream sequence
CAAGGCAGGACTGTGCTCCAGGCCTCTACAGTGGTGCCTGCATTCCATGGGTGacatacatgcacatgcacacatgcacacaaacacactcgggcacatg
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate