Basic Information
VIS ID
TVIS44032618
Fusion event
HTLV-1-EIF3A integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr10
Cytoband
q26.11
Reference genome
NCBI36/hg18
Start
120783638/119034136 (Hg38)
End
120783638/119034136 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
EIF3A
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-16-5p ; hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-484 ; hsa-let-7c-5p ; hsa-mir-488-3p
Nearest miRNA
hsa-mir-107/Upstream/1866362; hsa-mir-202/Downstream/343836;
Nearest TSS
ENST00000439456/Upstream/3710; ENST00000472379/Downstream/25754;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3267, chr10-CpG: 39/Downstream/8013
Upstream sequence
TCTCAATGAAACTGCAGAAGCCACCATGAACATGGAAGACCACCTAGCAGATCGGTGAGTAGGCTGCTTGTTCAGCTTTCCTTTAACACCTGTTGGTAAA
Downstream sequence
TACTAATGGGAGTAGACAGAGTTGTATGGCCTGGACAGTGGAAACCAAGAGCAGGATCGCAAAGTAACAGCATCAGACTCTTCTGCCCTCCTCTTGCACT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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