Basic Information
VIS ID
TVIS44032665
Fusion event
HTLV-1-KCNQ5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
NCBI36/hg18
Start
73655723/72889279 (Hg38)
End
73655723/72889279 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6D
Target gene
KCNQ5
miRNAs that regulate target gene
hsa-mir-190a-5p ; hsa-mir-194-3p ; hsa-mir-574-5p ; hsa-mir-6515-5p ; hsa-mir-6867-5p ; hsa-mir-7847-3p ; hsa-mir-3650 ; hsa-mir-4455 ; hsa-mir-6747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-6738-5p ; hsa-mir-5194 ; hsa-mir-1914-3p ; hsa-mir-6782-5p ; hsa-mir-5693 ; hsa-mir-675-3p ; hsa-mir-223-5p ; hsa-mir-543 ; hsa-mir-5096 ; hsa-mir-101-3p ; hsa-mir-139-5p ; hsa-mir-4999-3p ; hsa-mir-144-3p ; hsa-mir-6507-5p ; hsa-mir-4282
Nearest miRNA
hsa-mir-10398/Upstream/1485658; hsa-mir-10524/Downstream/78408;
Nearest TSS
ENST00000381078/Upstream/267107; ENST00000443915/Downstream/114717;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/265898, chr6-CpG: 22/Downstream/268582
Upstream sequence
tgcaaatatcgaatgaacagtattccaggcagcagcaacaataaagttaaagaccctggagtgtgattgtgcttggtgtgttgaagaacatcaaggaagt
Downstream sequence
cactgtggctggaacagaatgaggcagaggggaagcagattagataggaccttggagcctcggaagccactgggaagctttgATCAGAGAGCTACTCAAC
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate