Basic Information
VIS ID
TVIS44032680
Fusion event
HTLV-1-SRPRB integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
NCBI36/hg18
Start
135020286/133818752 (Hg38)
End
135020286/133818752 (Hg38)
Orient
-
Location type
Intronic
Target gene
SRPRB
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-488-3p ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-6760-5p ; hsa-mir-6878-5p ; hsa-mir-6892-5p ; hsa-mir-498 ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-5589-3p ; hsa-mir-6515-3p ; hsa-mir-8060 ; hsa-mir-510-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-6730-5p ; hsa-mir-146a-5p ; hsa-mir-5681a ; hsa-mir-4475 ; hsa-mir-7155-3p ; hsa-mir-3136-3p ; hsa-mir-4699-5p ; hsa-mir-676-5p ; hsa-mir-4724-5p ; hsa-mir-578 ; hsa-mir-4642 ; hsa-mir-891b
Nearest miRNA
hsa-let-7g/Upstream/1832821; hsa-mir-1224/Downstream/549052;
Nearest TSS
ENST00000440867/Upstream/7628; ENST00000482019/Downstream/75967;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/12397, chr3-CpG: 111/Downstream/75970
Upstream sequence
CTTAAAAAATATTAAAATGAATACCTATGTACTCACCACCATGCCTAGAAGGCCCCTGTTTCTCCCCAAAAGCTTTTCCCTCAAGAGGTCAGCAATATCC
Downstream sequence
AGTTTTGTATTGTTTTTTAAAAATACTTTTACAgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtgtTCCTTCCTAAACAAGGTATTGCTTAGTTT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate