Basic Information
VIS ID
TVIS44032686
Fusion event
HTLV-1-XRCC5 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
NCBI36/hg18
Start
216756448/216183480 (Hg38)
End
216756448/216183480 (Hg38)
Orient
-
Location type
Intronic
Target gene
XRCC5
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-7-5p ; hsa-mir-100-5p ; hsa-mir-26b-5p ; hsa-mir-7977 ; hsa-mir-4528 ; hsa-mir-584-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-29b-1-5p ; hsa-mir-361-5p ; hsa-mir-92a-2-5p ; hsa-mir-3927-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-31-5p ; hsa-mir-526b-5p ; hsa-mir-623
Nearest miRNA
hsa-mir-10b/Upstream/2425321; hsa-mir-1244-1/Downstream/1717033;
Nearest TSS
ENST00000437798/Upstream/52770; ENST00000485763/Downstream/20536;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/73939, chr2-CpG: 85/Downstream/187822
Nearest cancer related gene
XRCC5(TSG, No orient, 0)
Upstream sequence
TTAGTGCAATTTGTAAGAAATTACTGCACTTAATGAGAAAATCATTAAGCATGAAAAAATGGGCTCTGACTGAACTTGTGGAACTTAAATGGTGAGGTTT
Downstream sequence
TAATTGAGTTTTTTAGTTATTGGTAAGaataataataataatttaaaaataCAGGACTGCATCTGTGTGTTGAGGTGGTCAGCACTTTGCATATCTTAGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate