Basic Information
VIS ID
TVIS44032687
Fusion event
HTLV-1-ZNRF1 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
NCBI36/hg18
Start
73603810/75012411 (Hg38)
End
73603810/75012411 (Hg38)
Orient
-
Location type
Intronic
Target gene
ZNRF1
miRNAs that regulate target gene
hsa-mir-15b-5p ; hsa-mir-30a-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-4720-3p ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-214-3p ; hsa-mir-6746-3p ; hsa-mir-6838-5p ; hsa-mir-4690-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-3194-5p ; hsa-mir-6849-3p ; hsa-mir-4691-3p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1225/Upstream/4981989; hsa-mir-11401/Downstream/1856525;
Nearest TSS
ENST00000527434/Upstream/10114; ENST00000579084/Downstream/82733;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/12102, chr16-CpG: 41/Downstream/102089
Upstream sequence
CTTGGGTTAGAGAGCCAGAAGCCATTTATAGGCAGAACATCAGCTTTCTGGATTAAAGGATGGCTGTGGACCTAATGATGAGAATCTAGAGGTCATGGGG
Downstream sequence
AATTTCCTTACTGTCTGTGCCCCCCTTTTCCATATGGTCAGCTTGGTGCTTGGCACTGATCATGGCACACTTTACAAAAAGTGGATTCATATAAGGTCGT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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