Basic Information
VIS ID
TVIS44032700
Fusion event
HTLV-1-ZBTB21 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr21
Cytoband
q22.3
Reference genome
NCBI36/hg18
Start
42301771/42008593 (Hg38)
End
42301771/42008593 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZBTB21
miRNAs that regulate target gene
hsa-mir-548b-3p ; hsa-mir-186-5p ; hsa-mir-140-3p ; hsa-mir-101-3p ; hsa-mir-93-5p ; hsa-mir-425-5p ; hsa-mir-30e-5p ; hsa-mir-6507-5p ; hsa-mir-3119 ; hsa-mir-510-3p ; hsa-mir-488-3p ; hsa-mir-875-5p ; hsa-mir-4715-5p ; hsa-mir-4282 ; hsa-mir-6875-3p ; hsa-mir-2053 ; hsa-mir-569 ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-6845-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-7113-3p ; hsa-mir-4469 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-3919 ; hsa-mir-4756-3p ; hsa-mir-3620-3p ; hsa-mir-6865-3p
Nearest miRNA
hsa-let-7c/Upstream/261752; hsa-mir-5692b/Downstream/942335;
Nearest TSS
ENST00000624081/Upstream/536; ENST00000412906/Downstream/601;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/54313, chr21-CpG: 233/Downstream/577
Upstream sequence
tcacgccattgtactccagcctggggcaacaagagtgaaactctgtcaaaaaaaaaaaaaaaaaaaaaagaaaaaaagaaaagaaaagaaaaaaTTGTCC
Downstream sequence
CTTTAATTATCTCATTTCCATCGAGAGACCTTCTTAACTTAACCCCAATTTTGTTATTTACAATTTTTCCTTCAGAGTGTACACATCTAATATTCAACAG
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate