VISDB - VIS Detail

Basic Information

VIS ID

TVIS44032730

Fusion event

HTLV-1-GNB5 integration

Validated

Detection method

HTS

Data source

Curated

Sample type

Nontumor

Disease

Not given

Quality evaluation

Normal

Reported year

2019

PubMed ID

30307560

Virus Sequence

Virus name

HTLV-1

Subtype

HTLV-1c

Reference genome

KF242506

Host Sequence

Chromosome

chr15

Cytoband

q21.2

Reference genome

NCBI36/hg18

Start

50227211/52147722 (Hg38)

End

50227211/52147722 (Hg38)

Orient

Location type

Intronic

Target gene

GNB5

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-128-3p ; hsa-mir-148a-3p ; hsa-mir-27a-3p ; hsa-mir-26b-5p ; hsa-mir-425-5p ; hsa-mir-6807-5p ; hsa-mir-1292-3p ; hsa-mir-4279 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-4722-3p ; hsa-mir-6727-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-5089-5p ; hsa-mir-5589-5p ; hsa-mir-4731-5p ; hsa-mir-6778-3p ; hsa-mir-4707-3p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-150-5p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-186-3p ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-93-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p

Nearest miRNA

hsa-mir-10393/Upstream/833613; hsa-mir-11181/Downstream/129395;

Nearest TSS

ENST00000557528/Upstream/3261; ENST00000559779/Downstream/32165;

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/34941, chr15-CpG: 100/Downstream/31661

Upstream sequence

gttgcccaggctggagtgcagtggcacaatctcagctcactccaacatctgcctccggggttcaagcaattctcctatctcagcttcctaactgggatta

Downstream sequence

caggcatgcgccaccatgccaggctaatttttgtatttttagtaaagatggggtttcgccatgttggccaggctggtctcgaactcctgacttcaagtga

Reference

Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.