Basic Information
VIS ID
TVIS44032732
Fusion event
HTLV-1-RRAS2 integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr11
Cytoband
p15.2
Reference genome
NCBI36/hg18
Start
14326079/14347957 (Hg38)
End
14326079/14347957 (Hg38)
Orient
+
Location type
Intronic
Target gene
RRAS2
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-7-5p ; hsa-mir-93-5p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-624-3p ; hsa-mir-651-3p ; hsa-mir-23b-3p ; hsa-mir-580-3p ; hsa-mir-4697-3p ; hsa-mir-935 ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-548n ; hsa-mir-223-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p ; hsa-mir-106a-3p ; hsa-mir-3662 ; hsa-mir-2681-5p ; hsa-mir-7848-3p ; hsa-mir-1252-5p ; hsa-mir-944 ; hsa-mir-599 ; hsa-mir-3161 ; hsa-mir-19a-3p ; hsa-mir-4504 ; hsa-mir-549a ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-1255b-2-3p ; hsa-mir-4796-3p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-106b-5p ; hsa-mir-106a-5p
Nearest miRNA
hsa-mir-210/Upstream/2184190; hsa-let-7a-2/Downstream/1621576;
Nearest TSS
ENST00000527297/Upstream/5863; ENST00000532740/Downstream/6543;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/88339, chr11-CpG: 110/Downstream/10305
Nearest cancer related gene
RRAS2(OG, No orient, 0)
Upstream sequence
aaattCCAGTAGAAAAAAAAAAATCTACTTTCCAAAAACCACCACAGAACACAGAAAAAAACAAAAACAGTTGTACAGCAAAAGACACACTTGGTGCAAA
Downstream sequence
GGGAGGAAGTTATTATGCTAAATAAAGATTAGAGTTTATGGACAAAACCTTACTGGCCTAACCTAAATTTATCAACCTTTCCCTCCCAAGACATCTGGCT
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
Curate