Basic Information
VIS ID
TVIS44032748
Fusion event
HTLV-1-AAGAB integration
Validated
No
Detection method
HTS
Data source
Curated
Sample type
Nontumor
Disease
Not given
Quality evaluation
Normal
Reported year
2019
PubMed ID
30307560
Virus Sequence
Virus name
HTLV-1
Subtype
HTLV-1c
Reference genome
KF242506
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
NCBI36/hg18
Start
65325355/67245963 (Hg38)
End
65325355/67245963 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
AAGAB
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-92a-3p ; hsa-mir-7856-5p ; hsa-mir-576-5p ; hsa-mir-4263 ; hsa-mir-4477b ; hsa-mir-4799-5p ; hsa-mir-651-3p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-129-5p ; hsa-mir-3680-3p ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-3691-3p ; hsa-mir-3184-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1323 ; hsa-mir-1-5p ; hsa-mir-548o-3p
Nearest miRNA
hsa-mir-10393/Upstream/748929; hsa-mir-11181/Downstream/1555887;
Nearest TSS
ENST00000557528/Upstream/3092; ENST00000560497/Downstream/8691;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/179539, chr15-CpG: 62/Downstream/8488
Upstream sequence
GGAAAATTCAGACAGAACAGCCACCCTGTTACATCAAGATCACAGTGTTGTTTATTACCAAATGATCAAACATTTTCCTGATCTCAGCAGGCTGGAGTTT
Downstream sequence
GATCCAAATACAGTGACACTTTTTTCCACTTCTGTGTCAAACCAGCCATCAGGTCTGTATGGAAAATTAAACTCTAAATAGGTTTTTGTTACTGAACCTA
Reference
Turpin, J., et al. Impact of Hepatitis B Virus Coinfection on Human T-Lymphotropic Virus Type 1 Clonality in an Indigenous Population of Central Australia. J Infect Dis ,2019,219(4): 562-567.
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